Laboratory of
Medical Psychology
and Addiction

Discover the Researchgate profile of Salvatore Campanella

My main research objective is to find biological markers (especially electrophysiological) of cognitive functions specifically altered in various psychiatric pathologies (depression, anxiety, addiction, schizophrenia) that could help to better take care of these mental illnesses, in a complementary way to the classic psychotherapeutic and drug management.

My main research theme:

Investigate through brain imaging techniques (evoked potentials, functional magnetic resonance) cognitive deficits observable in many psychiatric populations, such as depression, anxiety, schizophrenia and the various forms of addiction.

Currently, my research focuses on three major axes:

1. study the effect of express drunk on the brain of young consumers;

2. attempt to define neurophysiological procedures readily usable in clinical environments and likely to improve cognitive management of psychiatric patients;

3. combine the simultaneous recording of the electroencephalogram with that of the functional magnetic resonance, in order to obtain the anatomical and temporal network linked to the decours of a specific cognitive task.

Teenager and young brain. Frontiers in Psychopathology, 9, 2724

 

1. Campanella, E. Schroder, MA Vanderhasselt, C Kornreich, P Verbanck, C Baeken, B Burle (2018). Short-term impact of tDCS over the right frontal inferior cortex on impulsive responses in a Go-Nogo task. Clinical EEG & Neuroscience, 49(6), 398-406

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List of (co-)directed and/or supervised master’s theses

 

(1) Nathalie Wauters de Besterfeld : Perception et catégorisation des expressions émotionnelles faciales (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 1999.

 

(2) Catherine Hanoteau : Données comportementales et neurophysiologiques sur le phénomène de perception catégorielle (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 1999.

 

(3) Frédéric Joassin : Approche anatomo – fonctionnelle de la récupération d’associations entre visages et noms propres au moyen de la tomographie par émission de positrons (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 2000.

 

(4) Cédric Gaspard : Corrélats neurophysiologiques de la discrimination des expressions faciales : une étude réalisée au moyen de la technique des potentiels évoqués (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 2001.

 

(5) Roxane Malu : L’influence du contexte émotionnel sur la reconnaissance des expressions faciales (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 2001.

 

(6) Sabrina Papier : Démence de type Alzheimer : étude de l’hypothèse de déconnexion corticale à partir d’une stratégie d’intégration visuo-auditive (co-directed by Salvatore Campanella et Martial Vanderlinden) : UCL ; 2001.

 

(7) Stéphanie Leclère : La perception des expressions faciales émotionnelles chez des personnes dépressives et non dépressives et l’influence du contexte émotionnel sur celle-ci (co-directed by Salvatore Campanella et Xavier Seron) : UCL ; 2002.

 

(8) Odile Baudry : Investigation à l’aide des potentiels évoqués du traitement implicite de l’expression faciale émotionnelle (directed by Salvatore Campanella) : UCL ; 2003.

 

(9) Veronica Gomez Kieffer : Etude comparative des effets causés par l’usage de 3,4-méthylène-dioxy-meth-anphétamine (MDMA, ecstasy) sur le cerveau humain au moyen des potentiels évoqués cognitifs (directed by Salvatore Campanella) : UCL ; 2003.

 

(10) Pierre Maurage : Corrélats électrophysiologiques de l’interaction visuo-auditive entre visages et noms propres (directed by Salvatore Campanella) : UCL ; 2003.

 

(11) Calogero Montedoro : A beautiful mind : the emotion question (directed by Salvatore Campanella) : UCL ; 2004.

 

(12) Marie-Eve Vanhooldandt: Traitements émotionnels chez des sujets à tendance psychopathique : une étude en potentiel évoqué (directed by Salvatore Campanella) : UCL ; 2004.

 

(13) Valérie Antoniali : Influence du type de conditionnement à la cocaïne sur la consommation ultérieure de cocaïne et d’autres produits : apport des modèles animaux (co-directed by Salvatore Campanella et Emmanuel Streel) : UCL ; 2004.

 

(14) Aurélie Mullier : Etude des interactions visuo-auditives sous-tendant le traitement de stimuli émotionnels : approche comportementale et électrophysiologique (co-directed by Salvatore Campanella et Frédéric Joassin) : UCL ; 2006.

 

(15) Christophe Callot : Exploration de potentiels évoqués chémosensitifs dans l’alcoolisme chronique, et mise en corrélation avec des variables cognitivo-cliniques (co-directed by Salvatore Campanella et Pierre Maurage) : UCL ; 2009.

 

(16) Céline Duterte : Corrélats électrophysiologiques du traitement d’expressions faciales émotionnelles modulé par une induction d’humeur par la musique : étude réalisée au moyen de la technique des potentiels évoqués (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 2009.

 

(17) Mélanie Saeremans : Etude des corrélats électrophysiologiques de l’Iowa Gambling Task par la technique des potentiels évoqués (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 2009.

 

(18) Sabine Meurrens : Exploration comportementale et électrophysiologique de l’inhibition de réponse face à des expressions faciales émotionnelles dans l’anxiété sociale (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 2009.

 

(19) Sophie Froidbise : L’intégration visuo-auditive des visages et des voix émotionnels dans les tendances dépressives et anxieuses : Analyse du potentiel évoqué P300 (co-directed by Salvatore Campanella et Raymond Bruyer) : UCL ; 2009.

 

(20) Julie De Clercq : Exploration des déficits entre fonctions exécutives chez des patients alcooliques et des patients dépressifs : distinction entre déficits de flexibilité, mise à jour et inhibition (co-directed by Pierre Maurage and Salvatore Campanella) : UCL ; 2009.

 

(21) Florence Martino : Etude des processus exécutifs intervenant dans les biais attentionnels de l’anxiété sociale au moyen d’une tâche d’antisaccade (co-directed by Mandy Rossignol and Salvatore Campanella) : UCL ; 2011.

 

(22) Hélène Soubre : Etude en potentiels évoqués de l’influence du contexte sur l’inhibition de la réponse dominante chez les étudiants répondant aux critères de binge drinking (co-directed by Charles Kornreich and Salvatore Campanella) : ULB ; 2011.

 

(23) Alexandra Husson : Les modulations de l’onde P300 chez des sujets à tendance dépressive : une sensibilité accrue lors de paradigmes oddball cross-modaux ? (co-directed by Charles Kornreich and Salvatore Campanella) : ULB ; 2011.

 

(24) Anouk Watillon : L’avantage d’un paradigme oddball bimodal lors de l’analyse de l’influence des facteurs de personnalité sur l’onde P300 (co-directed by Charles Kornreich and Salvatore Campanella) : ULB ; 2013.

 

(25) Agnieszka Cimochowska : Investigation of cognitive impairment in chronic alcoholism : response inhibition processing for alochol-related cues and phenomenon of relapse. An ERP study (co-directed by Charles Kornreich and Salvatore Campanella) : ULB ; 2013.

 

(26) Mathilde Heudier: L’évaluation neurophysiologique cognitive dans le traitement des maladies psychiatriques. Création d’une batterie de tests et récolte de données normatives (Supervised by Salvatore Campanella) : ULB ; 2015.

 

(27) Elena Mortier : Entrainement cognitif à une tâche Flanker-Go/NoGo : changements neuronaux associés à la fonction d’inhibition réactive (Supervised by Salvatore Campanella) : ULB ; 2015.

 

(28) Antoinette Vandenkerckhove : Analyse comparative de données comportementales et neurophysiologiques des composantes Nogo N200 et Nogo P300 récoltées lors d’une tâche dite d’inhibition de type Go/Nogo (Supervised by Salvatore Campanella) : ULB ; 2016.

 

(29) Amandine Dodémont : L’impact des techniques combinées de neuromodulation et d’entraînement cognitif sur la capacité d’inhibition à travers la neurophysiologie (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2017.

 

(30) Jessica Da Rocha : Effet de la stimulation transcrânienne à courant direct (tDCS) sur l’inhibition : Évaluation des composantes N200 et P300. Futures applications dans l’alcoolisme? (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2017.

 

(31) Sarah Dehaeseleer : Participation à la création d’une batterie d’évaluation neurophysiologique dans le traitement des maladies psychiatriques. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2017.

 

(32) Alexandru Dumitrescu : Recueil de données neurophysiologiques normatives sur les fonctions d’inhibition réactive et proactive. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2017.

 

(33) Florence Hanard : Approche psychophysiologique du traitement des maladies psychiatriques : élaboration de données normatives pour une batterie d’examen et analyse des variables influençant les potentiels évoqués chez des sujets contrôles. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2017.

 

(34) Liz Weyer : Analyse comparative des capacités inhibitrices chez les toxicomanes avec et sans dépendance aux opiacés par rapport aux sujets sains dans une tâche Go/Nogo modifiée : Une étude neurophysiologique du complexe Nogo-N2/P3. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2017.

 

(35) Macha Dubuson : Effet de la tDCS sur les composantes d’inhibition ERPs des joueurs compulsifs. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2017.

 

(36) Sarah-Jane Kessler : L’impact des récompenses monétaires sur les processus motivationnels chez le joueur pathologique. (Supervised by Salvatore Campanella and Xavier Noël) : ULB ; 2017.

 

(37) Philippe Ciers : The effects of transcranial direct current stimulation on cognitive control in harmful alcohol drinkers : a double-blind crossover study. Master of Medicine Ghent University Januari 2018 (Supervised by M-A Vanderhasselt and S Herremans).

 

(38) Lien Ruysschaert: The effects of transcranial direct current stimulation of the prefrontal cortex on alcohol craving: a double-blind crossover study. Master of Medicine Ghent University Januari 2018 (Supervised by M-A Vanderhasselt and S Herremans).

 

(39) Manon Gaudin: Investigation des corrélats neurophysiologiques des processus impliqués dans une tâche de mise à jour en mémoire de travail sur une population de sujets sains. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2018.

 

(40) Fadwa Jafar: Booster l’inhibition proactive pour diminuer la consummation d’alcool? (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2018.

 

(41) Manon Escoms: Le potentiel du vieillissement cognitif: évaluation neurophysiologique au sein de la population vieillissante. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2018.

 

(42) Anaid Perez Ramos: Les potentiels évoqués P300 et P50 dans une population de patients psychotiques et bipolaires. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2018.

(43) Valeria Casasanta: Investigation par le biais de la neurophysiologie des deficits d’inhibition dans une population de personnes obèses. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2018.

 

(44) Clemence Dousset: Etude de l’impact des techniques de neuromodulation sur les capacités d’inhibition. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2018.

 

(45) Sophie Felice: La validation de l’échelle “Eppendorf Schizophrenia Inventory” (ESI) en version française chez des sujets souffrant de schizophrénie. (Supervised by Salvatore Campanella and Hendrik Kajosch) : ULB ; 2018.

 

(46) Joy Vrancken: Etude electrophysiologique en psychiatrie: la MMN et la Nogo-N2/P3 dans la bipolarité et la psychose. (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2018.

 

(47) Nicolas Malbrouqui: Etude de la P300 comme marqueur état de la schizophrénie à travers un paradigm oddball bimodal: étude de follow-up. (Supervised by Salvatore Campanella and Hendrik Kajosch) : ULB ; 2018.

 

(48) Mariane Bailly: Effets de la tdcs sur les composantes d’inhibition ERPs des joueurs compulsifs (Supervised by Salvatore Campanella and Elisa Schroder) : ULB ; 2019.

 

List of (co-)directed and/or supervised doctoral Theses

(1) 03 december 2004: Sylvain Delplanque: Information émotionnelle et composantes évoquées P3a et P3b. University of Lille, France (Advisor: Henrique Sequeira). My role: foreign expert evaluation.

 

(2) 29 march 2006: Frédéric Joassin: Etude des corrélats cérébraux sous-tendant les processus associatifs impliqués dans l’identification des personnes. University of Louvain, Belgium (Co-directed by Raymond Bruyer and Salvatore Campanella).

 

(3) 20 march 2008: Pierre Maurage: Déficit de décodage des expressions faciales émotionnelles dans l’alcoolisme. Exploration comportementale et électrophysiologique. University of Louvain, Belgium (Co-directed by Raymond Bruyer and Salvatore Campanella).

 

(4) 19 december 2008: Simon Rigoulot: Impact comportemental et électrophysiologique de l’information émotionnelle en vision périphérique. University of Lille, France (Advisor: Henrique Sequeira). My role: foreign expert evaluation.

 

(5) 16 april 2009: Mandy Rossignol: Exploration électrophysiologique des biais attentionnels envers les expressions faciales émotionnelles dans l’anxiété. University of Louvain (UCL), Belgium (Co-directed by Pierre Philippot and Salvatore Campanella).

 

(6) 20 mei 2009: Solange Mardaga: La personnalité comme modulateur de la réactivité émotionnelle: une approche psychophysiologique. University of Liège (ULG), Belgium (Advisor: Michel Hansenne). My role: expert evaluation.

 

(7) 15 october 2009: Aurélie Foucher: Dynamique temporelle de la perception émotionnelle et anxiété-trait. University Pierre-Marie Curie, Paris, France (Advisor : Stéphanie Dubal). My role: foreign expert evaluation.

 

(8) 20 september 2011: Fabien D’Hondt: Emotion et Espace Visuel: Approches neuromagnétique, neurosomatique et comportementale. University of Lille, France (Advisor: Henrique Sequeira). My role: foreign expert evaluation.

 

(9) 25 mei 2012: Catherine Barsics: Access to semantic and episodic information from faces and voices. University of Liège (ULG), Belgium (Advisor: Serge Brédart). My role: expert evaluation.

 

(10) 26 september 2013: Thibaut Dumas: Etude en MEG de la contribution de l’amygdale à la perception des personnes: de la perception des visages à la coprésence. University Pierre-Marie Curie, Paris 6, France (co-directed by Stéphanie Dubal and Nathalie George). My role: foreign expert evaluation.

 

(11) 05 mei 2014: Géraldine Petit: Identification de marqueurs neurophysiologiques pronostiques de la rechute dans l’alcoolo-dépendance. University of Brussels (ULB), Belgium (Co-directed by Charles Kornreich and Salvatore Campanella).

 

(12) 16 december 2015: Giulia Bucchioni: Study of postural, physiological and corticospinal responses in empathy for pain and pain anticipation. University of Picardie, Amiens, France (co-directed by Pierre Krystkowiak and Harold Mouras). My role: foreign expert evaluation.

 

(13) 15 mars 2016 : Julien Delannoy: Sommeil et régulation émotionnelle. Approche neurodynamique. University of Lille, France (Advisor: Henrique Sequeira). My role: foreign expert evaluation.

 

(14) 18 avril 2016 : Dyna Delle-Vigne: « Two is better than one » : Une proposition pour réhabiliter l’usage de la P300 audio-visuelle en routine clinique. University of Brussels (ULB), Belgium (Co-directed by Charles Kornreich and Salvatore Campanella).

 

(15) 26 januari 2017: Sybille Horat: “Electrophysiological correlates of attention, working memory and decision-making in healthy controls and psychotic patients “. University of Fribourg, Switzerland (Advisor: Marco Merlo).

 

(16) 23 januari 2018: Séverine Lannoy: “Explorinq the imbalance between affective and reflective systems in binqe drinking. A behavioral and electrophvsioloqical approach”. University of Louvain (UCL), Belgium (Advisor: Pierre Maurage/Joël Billieux).

 

(17) 02 februari 2018: Gilles Naëije: “Insights into the neural bases of tactile change detection from magnetoencephalography”. University of Brussels (ULB), Belgium (Advisor: Xavier De Tiège).

Sous presse – Acceptés

S. Amenta, X. Noël, P. Verbanck, S. Campanella (2012). Decoding of emotional components in complex communicative situations (irony) and their relations to empathic abilities in male chronic alcoholics: An issue for treatment. Alcoholism: Clinical and Experimental Research, in press.

C. Kornreich, D. Delle Vigne, S. Campanella, X. Noël, C. Papageorgiou, O. Brown, P. Verbanck, E. Ermer. Conditional reasoning difficulties in polysubstance dependence patients. Psychology of Addictive Behaviors, in press.

X. Noël, M. Van der Linden, D. Brewers, S. Campanella, C. Hanak, P. Verbanck. The contribution of executive functions deficits to impaired episodic memory in individuals with alcoholism. Psychiatry Research, in press.

C. Kornreich, D. Brevers, D. Canivet, E. Ermer, C. Naranjo, E. Constant, P. Verbanck, S. Campanella, X. Noël. Impaired processing of emotion in music, faces and voices supports a generalized emotional decoding deficit in alcoholism. Addiction, in press.

Projets obtenus comme investigateur principal

ERAB: The European Foundation for Alcohol Research – 100 000 euros for 2 years (2011-12) – ref. EA 10 30: “Binge drinking: cognitive and brain impairment and their association with immune response”.

FNRS – Crédit au Chercheur – 16 600 euros for one year – “Binge drinking impact on neurocognitive functioning

Main topic of research

For the next few years, my research projects will develop mainly along two axes:

• The first axis will be the development of a research activity on the role played by sleep in the pathophysiology of psychiatric disorders. Indeed, in the continuity of the research work of my thesis, it is important to continue research on the identification of electrophysiological markers related to sleep for psychiatric disorders. In this context, the development of specific care pathways (including comprehensive sleep assessments) for the different clinical populations present within the psychiatry department of the Brugmann University Hospital should be a priority in order to be able to implement both clinical studies (epidemiology, etc.) and fundamental studies (analyses of the different signals measured during polysomnographies, etc.).
• The second axis will be the development of a research activity on mood disorders resistant to treatment. Indeed, it is important to be able to better identify markers of resistance to treatments in these patients in order to develop more appropriate therapeutic strategies. In this context, the development of specific care pathways (including treatments with esketamine, transcranial magnetic stimulation and electroconvulsive therapy) for patients with treatment-resistant mood disorders within the psychiatry department of the Brugmann University Hospital should be a priority in order to be able to implement both clinical studies (identification of clinical risk factors, etc.) and fundamental studies (analyses of the different electrophysiological measurements in relation to stimulation treatments, etc.).

(CO-)SUPERVISED PhD THESES:

Ongoing:

Anaïs Mungo (advisor)

Title: L’impulsivité dans le trouble de personnalité borderline de l’adolescence à l’âge adulte: Caractéristiques, facteurs de risque et intervention précoce

Daniel FRENCH (advisor)

Title: Contribution à l’exploration du concept de triade sombre et de ses liens avec les déficits émotionnels chez l’individu normatif et souffrant de psychopathologie

Véronique Bernier (advisor)

Title: Contribution à l’étude de la physiopathologie de la dépression majeure, par l’étude des facteurs de risques nutritionnels et symptomatologiques, pouvant contribuer à soutenir un contexte oxydatif et inflammatoire délétère et accélérer le processus de vieillissement

 

SCIENTIFIC PUBLICATIONS

(75 publications, 977 citations, h-index 19; from Google Scholar)

5 MOST CITED PUBLICATIONS

–        Hein M, Lanquart JP, Loas G, Hubain P, Linkowski P. Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects. Respir Res. 2017;18(1):135.

–        Hein M, Lanquart JP, Loas G, Hubain P, Linkowski P. Prevalence and risk factors of excessive daytime sleepiness in major depression: A study with 703 individuals referred for polysomnography. J Affect Disord. 2019;243:23-32.

–        Hein M, Lanquart JP, Loas G, Hubain P, Linkowski P. Similar polysomnographic pattern in primary insomnia and major depression with objective insomnia: a sign of common pathophysiology? BMC Psychiatry. 2017;17(1):273.

–        Hein M, Lanquart JP, Loas G, Hubain P, Linkowski P. Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in major depression: an observational and retrospective study on 703 subjects. BMC Pulm Med. 2017;17(1):165.

–        Hein M, Lanquart JP, Loas G, Hubain P, Linkowski P. Prevalence and risk factors of type 2 diabetes in insomnia sufferers: A study on 1311 individuals referred for sleep examinations. Sleep Med. 2018;46;37-45.

LAST FIVE YEARS PUBLICATIONS (2021-2025)

2021

• Hein M, Mungo A. [Esketamine in the management of treatment-resistant depression: what prospects for 2021?]. Rev Med Brux. 2021;42(2):124-127.
• Hein M. Série thématique: Qu’est-ce que la psychiatrie? Rev Med Brux. 2021;42(6):443.
• Djocgoue C, Hein M, Lanquart JP, Mungo A, Loas G. [Risk of excessive alcohol consumption associated with sleep complaints in major depressed individuals]. Rev Med Brux. 2021;42(6):463-472.
• Boz S, Lanquart JP, Mungo A, Delhaye M, Loas G, Hein M. Risk of Excessive Daytime Sleepiness Associated to Major Depression in Adolescents. Psychiatr Q. 2021;92(4):1473-1488.
• Zeoli I, Lanquart JP, Wacquier B, Mungo A, Loas G, Hein M. Polysomnographic markers of suicidal ideation in untreated unipolar major depressed individuals. Int J Psychophysiol. 2021;166:19-24.
• Bouchart C, Engelholm JL, Closset J, Navez J, Loi P, Gökburun Y, De Grez T, Mans L, Hendlisz A, Bali MA, Eisendrath P, Van Gestel D, Hein M, Moretti L, Van Laethem JL. Isotoxic high-dose stereotactic body radiotherapy integrated in a total multimodal neoadjuvant strategy for the treatment of localized pancreatic ductal adenocarcinoma. Ther Adv Med Oncol. 2021;13:17588359211045860.

 

2022

• Hein M, Mungo A. [Esketamine in the management of treatment-resistant depression: what prospects for 2021?]. Rev Med Brux. 2021;42(2):124-127.
• Hein M, Lanquart J-P, Mungo A, Loas G. Cardiovascular risk associated with co-morbid insomnia and sleep apnoea (COMISA) in type 2 diabetics. Sleep Sci. 2022;15(Spec 1):184-194.
• Hein M, Wacquier B, Lanquart JP, Loas G. Risk of Cardiovascular Disease in Apnoeic Individuals: Role of Comorbid Insomnia Disorder. Life (Basel). 2022;12(7):944.
• Hein M, Mungo A, Loas G. Nonremission After Electroconvulsive Therapy in Individuals With Major Depression: Role of Borderline Personality Disorder. J ECT. 2022;38(4):238-243.
• Hein M, Mungo A, Loas G. Risk of relapse within 6 months associated with borderline personality disorder in major depressed individuals treated with electroconvulsive therapy. Psychiatry Res. 2022;314:114650.
• Hein M, Dekeuleneer F-X, Hennebert O, Skrjanc D, Oudart E, Mungo A, Rotsaert M, Loas G. Relationships between Recent Suicidal Ideation and Recent, State, Trait and Musical Anhedonias in Depression. Int J Environ Res Public Health. 2022;19(23):16147.
• Hein M. Migration et santé mentale: quelles perspectives alors que les réfugiés ukrainiens affluent à travers l’Europe. Rev Med Brux. 2022;43(5):471-472.
• Mungo A, Hein M, Lanquart JP, Loas G. [Atypical depression as a risk factor for obstructive sleep apnea syndrome in young adults]. Encephale. 2022;48(2):171-178.
• Manderlier M, Navez J, Hein M, Engelholm J-L, Closset J, Bali MA, Van Gestel D, Moretti L, Van Laethem J-L, Bouchart C. Isotoxic High-Dose Stereotactic Body Radiotherapy (iHD-SBRT) Versus Conventional Chemoradiotherapy for Localized Pancreatic Cancer: A Single Cancer Center Evaluation. Cancers. 2022;14(23):5730.
• Damerdji F, Rotsaert M, Wacquier B, Hein M, Loas G. Prevalence and Relationships between Alexithymia, Anhedonia, Depression and Anxiety during the Belgian COVID-19 Pandemic Lockdown. Int J Environ Res Public Health. 2022;19(22):15264.
• Dosogne M, Wacquier B, Al Faker M, Willame H, Point C, Loas G, Hein M. Risk of current suicidal ideations associated with lifelong anhedonia and recent change of anhedonia in individuals with insomnia: A cross-sectional study. J Psychiatr Res. 2022;150:338-345.
• Willame H, Wacquier B, Point C, Dosogne M, Al Faker M, Loas G, Hein M. The association between type 2 diabetes and anhedonic subtype of major depression in hypertensive individuals. J Clin Hypertens (Greenwich). 2022;24(2):156-166.
• Point C, Wacquier B, Dosogne M, Al Faker M, Willame H, Loas G, Hein M. Impact of Alexithymia on the Lipid Profile in Major Depressed Individuals. J Lipids. 2022;2022:5450814.
• Al Faker M, Wacquier B, Willame H, Point C, Dosogne M, Loas G, Hein M. The association between type 2 diabetes and major depression in apnoeic individuals. Sleep Biol. Rhythms. 2022;20(2):219-228.
• Laoufi MA, Wacquier B, Lartigolle T, Loas G, Hein M. Suicidal Ideation in Major Depressed Individuals: Role of Type D Personality. J Clin Med. 2022;11(22):6611.
• Mungo A, Hein M. [The efficacy of esketamine in resistant major depressive disorder: A systematic review of the literature]. Encephale. 2022;48(4):455-461.
• Point C, Hein M. [Pregabalin misuse: an emerging public health problem]. Rev Med Brux. 2022;43(2):165-168.
• Willame H, Hein M. [Biannly® (paliperidone palmitate 6-month Long-Acting Injectable) in the maintenance treatment of schizophrenia]. Rev Med Brux. 2022;43(6):620-623.
• Ramdani Y, Leemans C, Hein M. [Cariprazine (Reagila®) for treatment of negative symptoms in patients with schizophrenia]. Rev Med Brux. 2022;43(6):624-627.
• Point C, Hein M. Burn-out chez l’étudiant en médecine et le médecin en formation: quelles perspectives thérapeutiques en 2022? Rev Med Brux. 2022;43(1):3.

2023

• Hein M, Mungo A. [Esketamine in the management of treatment-resistant depression: what prospects for 2021?]. Rev Med Brux. 2021;42(2):124-127.
• Bernier V, Debarge MH, Hein M, Ammendola S, Mungo A, Loas G. Major Depressive Disorder, Inflammation, and Nutrition: A Tricky Pattern? Nutrients. 2023;15(15):3438.
• Draelants L, Point C, Wacquier B, Lanquart JP, Loas G, Hein M. 10-Year Risk for Cardiovascular Disease Associated with COMISA (Co-Morbid Insomnia and Sleep Apnea) in Hypertensive Subjects. Life (Basel). 2023;13(6):1379.
• Darquennes G, Wacquier B, Loas G, Hein M. Suicidal Ideations in Major Depressed Subjects: Role of the Temporal Dynamics of Anhedonia. Brain Sci. 2023;13(7):1065.
• Leemans C, Ramdani Y, Hein M. [Clozapine (Leponex®): an effective treatment but not without risk!]. Rev Med Brux. 2023;44(1):50-54.
• Billion Z, Willame H, Hein M. [Two-injection start regimen of one-month long-acting aripiprazole (Abilify Maintena®) combined with a single oral dose for the maintenance treatment of schizophrenia]. Rev Med Brux. 2023;44(5):504-506.
• Dauchot C, Hein M. [Outpatient screening for obstructive sleep apnea-hypopnea syndrome: what place for the Sunrise device?]. Rev Med Brux. 2023;44(6):607-613.

 

2024

• Hein M, Mungo A. [Esketamine in the management of treatment-resistant depression: what prospects for 2021?]. Rev Med Brux. 2021;42(2):124-127.
• Hein M, Wacquier B, Conenna M, Lanquart JP, Point C. Impact of Intermittent Hypoxia Related to Obstructive Sleep Apnoea Syndrome on Low-Grade Inflammation in Hypertensive Patients: Potential Implications for Cardiovascular Risk. Life (Basel). 2024;14(5):592.
• Hein M, Wacquier B, Conenna M, Lanquart JP, Point C. Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA. Life (Basel). 2024;14(5):644.
• Hein M, Wacquier B, Conenna M, Lanquart JP, Point C. Risk of Comorbid Insomnia Disorder Associated with Major Depression in Apneic Patients: A Cross-Sectional Study. Clocks Sleep. 2024;6(3):389-401.
• Hein M, Wacquier B, Conenna M, Lanquart JP, Point C. The Association between Suicidal Ideation and Subtypes of Comorbid Insomnia Disorder in Apneic Individuals. J Clin Med. 2024;13(19):5907.
• Abdessater L, Hein M, Rasquin F. Analysis of Macular Vascularization Using Optical Coherence Tomography Angiography in Patients with Obstructive Sleep Apnea Syndrome: A Prospective Clinical Study. Medicina (Kaunas). 2024;60(5):757.
• Dossa A, Hein M, Bikrani O, Wacquier B, Point C. Impact of Comorbid Personality Disorder on the Risk of Involuntary Hospitalization in Patients Referred for Urgent Forensic Assessment: A Cross-Sectional Study. Brain Sci. 2024;14(10):961.
• Taton O, Viesca M, Njimi H, Van Ouytsel P, Hein M, Huberty V. A Pilot Study of an Endoluminal-Suturing Device as a Treatment Strategy for Patients With Obesity and Obstructive Sleep Apnea. Sleep Med Res. 2024;15(3):203-209.
• Mungo A, Delhaye M, Blondiau C, Hein M. Identity Formation in Individuals between 16 and 25 Years Old with Borderline Personality Disorder. J Clin Med. 2024;13(11):3221.
• Younes A, Point C, Wacquier B, Lanquart JP, Hein M. Excessive Daytime Sleepiness in Hypertensive Patients: The Role of Major Depressive Disorder. Diagnostics (Basel). 2024;14(17):1854.
• Bernier V, Alsaleh G, Point C, Wacquier B, Lanquart JP, Loas G, Hein M. Low-Grade Inflammation Associated with Major Depression Subtypes: A Cross-Sectional Study. Brain Sci. 2024;14(9):850.
• Bamouss A, Mungo A, Hein M. [Impact of the diagnostic method for borderline personality disorder on the acute response and the risk of early relapse in major depressed individuals treated with ECT: A systematic literature review]. Encephale. 2024;50(4):436-445.

 

2025

 

–        Hein M, Bouchart C. Impact of Depression on Mortality in Patients with Pancreatic Cancer: A Systematic Review. Curr Oncol. 2025;32(9):511.

–        El Helou M, Hein M, Cimpaye BC, Wacquier B, Mungo A. First Episode Psychosis in Patients Aged 18 to 30 Admitted Involuntarily: Characteristics and Risk Factors for Functional Non-Remission. Brain Sci. 2025;15(7):697.

–        Campanella S, Sistiaga S, Dousset C, Ingels A, Hanak C, Hein M, Kajosch H. Abstinence in recently detoxified AUD patients is subtended by increased inhibitory neural resources: A retrospective event-related potentials study. Int J Psychophysiol. 2025;214:113203.

–        Conenna M, Point C, Wacquier B, Lanquart JP, Hein M. Risk of Major Depression Associated with Excessive Daytime Sleepiness in Apneic Individuals. Clocks Sleep. 2025;7(2):22.

–        Ghayad T, Mungo A, Hein M. Prevalence and Clinical Impact of Restless Legs Syndrome in Pediatric Populations with Attention-Deficit/Hyperactivity Disorder: A Systematic Review. Clocks Sleep. 2025;7(3):50.

–        Mungo A, Delhaye M, Hein M. Multidimensional Impulsivity Profile in Young Adults Aged 16 to 25 with Borderline Personality Disorder: A Study Based on the UPPS-P Model. J Clin Med. 2025;14(19):7109.

–        Billion Z, Hein M. [Impact of the legalization of recreational cannabis on the risk of psychosis: A systematic review of the literature]. Encephale. 2025;51(2):186-201.

 

In October 2011, I obtained from the National Fund for Scientific Research (FNRS) a mandate of indefinite research on the study of implicit and explicit cognitive processes (and their cerebral substrates) involved in vulnerability, development, the maintenance and relapse of the addictive phenomenon.

My research interests in people with behavioral addictions (eg, pathological gambling) and substances (eg, alcohol dependence) are as follows:

– Study of motivational systems: approach and avoidance trends, attention bias, memory bias

– Study of self-regulation resources (inhibition, flexibility, updating, etc.)

– Study of the components of decision-making under uncertainty (risk management, intuition, etc.)

– How to restore self-control over addictive behaviors? Study of cognitive remediation strategies

-Study of social cognitive (treatment of emotions, theory of the mind, etc.)

– Computational approach to decision making: dilemne exploitation / exploration; model-based and model-free reinforcement learning

– Study of dissociative states related to decision-making in people with addictive behaviors

– Multivariate modeling (cognitive processing, thoughts, expectations, relationships to others, life events, etc.) addictive behaviors

– Goal-oriented systems and habits: what level of relevance in addictive behaviors?

 

Main collaborations

– Professor Antoine Bechara, University of Southern California, USA

– Professor Frederick Verbruggen, University of Ghent, Belgium

– Professor Nathaniel Daw, Pricetown University, USA

– Professor Tony Buchanan, University of St-Louis

– Professor Armand Chatard, Université de Poitiers

– Professor Nemat Jaafari, Université de Poitiers

– Professor Carole Fantini, Université Libre de Bruxelles

 

Publications

https://www.researchgate.net/profile/Xavier_Noel/research